Low Folding Cooperativity of Hp35 Revealed by Single-Molecule Force Spectroscopy and Molecular Dynamics Simulation

Some small proteins, such as HP35, fold at submicrosecond timescale with low folding cooperativity. Although these proteins have been extensively investigated, still relatively little is known about their folding mechanism. Here, using single-molecule force spectroscopy and steered molecule dynamics...

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Bibliographic Details
Main Authors: Lv, Chunmei, Tan, Cheng, Qin, Meng, Zou, Dawei, Cao, Yi, Wang, Wei
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2012
Subjects:
Protein
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328709/
https://ncbi.nlm.nih.gov/pubmed/22768951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.03.028
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