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Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice

Although cancer tends to affect the elderly, most preclinical studies are performed in young subjects. In this study, we developed a melanoma-specific cancer immunotherapy that shows efficacy in aged but not young hosts by mitigating age-specific tumor-associated immune dysfunction. Both young and a...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Hurez, Vincent, Daniel, Benjamin J., Sun, Lishi, Liu, Ai-Jie, Ludwig, Sara M., Kious, Mark J., Thibodeaux, Suzanne R., Pandeswara, Srilakshmi, Murthy, Kruthi, Livi, Carolina B., Wall, Shawna, Brumlik, Michael J., Shin, Tahiro, Zhang, Bin, Curiel, Tyler J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2012
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328641/
https://ncbi.nlm.nih.gov/pubmed/22496463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3019
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