Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice

Although cancer tends to affect the elderly, most preclinical studies are performed in young subjects. In this study, we developed a melanoma-specific cancer immunotherapy that shows efficacy in aged but not young hosts by mitigating age-specific tumor-associated immune dysfunction. Both young and a...

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Hlavní autoři: Hurez, Vincent, Daniel, Benjamin J., Sun, Lishi, Liu, Ai-Jie, Ludwig, Sara M., Kious, Mark J., Thibodeaux, Suzanne R., Pandeswara, Srilakshmi, Murthy, Kruthi, Livi, Carolina B., Wall, Shawna, Brumlik, Michael J., Shin, Tahiro, Zhang, Bin, Curiel, Tyler J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328641/
https://ncbi.nlm.nih.gov/pubmed/22496463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3019
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