TgMAPK1 is a Toxoplasma gondii MAP kinase that hijacks host MKK3 signals to regulate virulence and interferon-γ-mediated nitric oxide production

The parasite Toxoplasma gondii controls tissue-specific nitric oxide (NO), thereby augmenting virulence and immunopathology through poorly-understood mechanisms. We now identify TgMAPK1, a Toxoplasma mitogen-activated protein kinase (MAPK), as a virulence factor regulating tissue-specific parasite b...

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Publicado no:Exp Parasitol
Main Authors: Brumlik, Michael J., Pandeswara, Srilakshmi, Ludwig, Sara M., Jeansonne, Duane P., Lacey, Michelle R., Murthy, Kruthi, Daniel, Benjamin J., Wang, Rong-Fu, Thibodeaux, Suzanne R., Church, Kristina M., Hurez, Vincent, Kious, Mark J., Zhang, Bin, Alagbala, Adebusola, Xia, Xiaojun, Curiel, Tyler J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226171/
https://ncbi.nlm.nih.gov/pubmed/23541881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exppara.2013.03.016
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