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Evidence that monoclonal antibodies directed against the integrin β subunit PSI domain stimulate function by inducing receptor extension

The overall structure of integrins is that of a ligand-binding head connected to two long legs. The legs can exhibit a pronounced bend at the ‘knee’, and this region has been proposed to undergo a dramatic straightening when integrins transit from a low affinity to a high affinity state. The knee co...

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מידע ביבליוגרפי
Main Authors: Mould, A. Paul, Travis, Mark A., Barton, Stephanie J., Hamilton, Jennifer A., Askari, Janet A., Craig, Susan. E., McDonald, Philip, Kammerer, Richard A., Buckley, Patrick A., Humphries, Martin J.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2004
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328395/
https://ncbi.nlm.nih.gov/pubmed/15557320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M412240200
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