Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION

We previously demonstrated that Arg-Gly-Asp (RGD)-containing ligand-mimetic inhibitors of integrins are unable to dissociate pre-formed integrin-fibronectin complexes (IFCs). These observations suggested that amino acid residues involved in integrin-fibronectin binding become obscured in the ligand-...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mould, A. Paul, Askari, Janet A., Byron, Adam, Takada, Yoshikazu, Jowitt, Thomas A., Humphries, Martin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076510/
https://ncbi.nlm.nih.gov/pubmed/27484800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.736942
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