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Evidence that monoclonal antibodies directed against the integrin β subunit PSI domain stimulate function by inducing receptor extension
The overall structure of integrins is that of a ligand-binding head connected to two long legs. The legs can exhibit a pronounced bend at the ‘knee’, and this region has been proposed to undergo a dramatic straightening when integrins transit from a low affinity to a high affinity state. The knee co...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3328395/ https://ncbi.nlm.nih.gov/pubmed/15557320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M412240200 |
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