DNA damage–inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger

Nonproteolytic ubiquitylation of chromatin surrounding deoxyribonucleic acid (DNA) double-strand breaks (DSBs) by the RNF8/RNF168/HERC2 ubiquitin ligases facilitates restoration of genome integrity by licensing chromatin to concentrate genome caretaker proteins near the lesions. In parallel, SUMOyla...

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Main Authors: Danielsen, Jannie Rendtlew, Povlsen, Lou Klitgaard, Villumsen, Bine Hare, Streicher, Werner, Nilsson, Jakob, Wikström, Mats, Bekker-Jensen, Simon, Mailand, Niels
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2012
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328386/
https://ncbi.nlm.nih.gov/pubmed/22508508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201106152
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