Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics

It was reported previously that isolated human islets from individuals with type 2 diabetes mellitus (T2DM) show reduced glucose-stimulated insulin release. To assess the possibility that impaired bioenergetics may contribute to this defect, glucose-stimulated respiration (V̇o(2)), glucose usage and...

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Bibliografiske detaljer
Main Authors: Doliba, Nicolai M., Qin, Wei, Najafi, Habiba, Liu, Chengyang, Buettger, Carol W., Sotiris, Johanna, Collins, Heather W., Li, Changhong, Stanley, Charles A., Wilson, David F., Grimsby, Joseph, Sarabu, Ramakanth, Naji, Ali, Matschinsky, Franz M.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328091/
https://ncbi.nlm.nih.gov/pubmed/21952036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00218.2011
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