Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics

It was reported previously that isolated human islets from individuals with type 2 diabetes mellitus (T2DM) show reduced glucose-stimulated insulin release. To assess the possibility that impaired bioenergetics may contribute to this defect, glucose-stimulated respiration (V̇o(2)), glucose usage and...

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Detalhes bibliográficos
Main Authors: Doliba, Nicolai M., Qin, Wei, Najafi, Habiba, Liu, Chengyang, Buettger, Carol W., Sotiris, Johanna, Collins, Heather W., Li, Changhong, Stanley, Charles A., Wilson, David F., Grimsby, Joseph, Sarabu, Ramakanth, Naji, Ali, Matschinsky, Franz M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328091/
https://ncbi.nlm.nih.gov/pubmed/21952036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00218.2011
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