The HSP90 Inhibitor NVP-AUY922 Radiosensitizes by Abrogation of Homologous Recombination Resulting in Mitotic Entry with Unresolved DNA Damage

BACKGROUND: Heat shock protein 90 (HSP90) is a molecular chaperone responsible for the conformational maintenance of a number of client proteins that play key roles in cell cycle arrest, DNA damage repair and apoptosis following radiation. HSP90 inhibitors exhibit antitumor activity by modulating th...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Zaidi, Shane, McLaughlin, Martin, Bhide, Shreerang A., Eccles, Suzanne A., Workman, Paul, Nutting, Christopher M., Huddart, Robert A., Harrington, Kevin J.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327673/
https://ncbi.nlm.nih.gov/pubmed/22523597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035436
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы