The HSP90 Inhibitor NVP-AUY922 Radiosensitizes by Abrogation of Homologous Recombination Resulting in Mitotic Entry with Unresolved DNA Damage

BACKGROUND: Heat shock protein 90 (HSP90) is a molecular chaperone responsible for the conformational maintenance of a number of client proteins that play key roles in cell cycle arrest, DNA damage repair and apoptosis following radiation. HSP90 inhibitors exhibit antitumor activity by modulating th...

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Detalhes bibliográficos
Main Authors: Zaidi, Shane, McLaughlin, Martin, Bhide, Shreerang A., Eccles, Suzanne A., Workman, Paul, Nutting, Christopher M., Huddart, Robert A., Harrington, Kevin J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327673/
https://ncbi.nlm.nih.gov/pubmed/22523597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035436
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