B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor–transduced T cells

We conducted a clinical trial to assess adoptive transfer of T cells genetically modified to express an anti-CD19 chimeric Ag receptor (CAR). Our clinical protocol consisted of chemotherapy followed by an infusion of anti–CD19-CAR–transduced T cells and a course of IL-2. Six of the 8 patients treate...

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Autors principals: Kochenderfer, James N., Dudley, Mark E., Feldman, Steven A., Wilson, Wyndham H., Spaner, David E., Maric, Irina, Stetler-Stevenson, Maryalice, Phan, Giao Q., Hughes, Marybeth S., Sherry, Richard M., Yang, James C., Kammula, Udai S., Devillier, Laura, Carpenter, Robert, Nathan, Debbie-Ann N., Morgan, Richard A., Laurencot, Carolyn, Rosenberg, Steven A.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Plenary Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327450/
https://ncbi.nlm.nih.gov/pubmed/22160384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-384388
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