Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

In an attempt to treat cancer patients with ERBB2 overexpressing tumors, we developed a chimeric antigen receptor (CAR) based on the widely used humanized monoclonal antibody (mAb) Trastuzumab (Herceptin). An optimized CAR vector containing CD28, 4-1BB, and CD3ζ signaling moieties was assembled in a...

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Detalhes bibliográficos
Main Authors: Morgan, Richard A, Yang, James C, Kitano, Mio, Dudley, Mark E, Laurencot, Carolyn M, Rosenberg, Steven A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862534/
https://ncbi.nlm.nih.gov/pubmed/20179677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.24
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