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Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

In an attempt to treat cancer patients with ERBB2 overexpressing tumors, we developed a chimeric antigen receptor (CAR) based on the widely used humanized monoclonal antibody (mAb) Trastuzumab (Herceptin). An optimized CAR vector containing CD28, 4-1BB, and CD3ζ signaling moieties was assembled in a...

詳細記述

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書誌詳細
主要な著者: Morgan, Richard A, Yang, James C, Kitano, Mio, Dudley, Mark E, Laurencot, Carolyn M, Rosenberg, Steven A
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862534/
https://ncbi.nlm.nih.gov/pubmed/20179677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.24
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