T cells expressing an anti–B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma

Therapies with novel mechanisms of action are needed for multiple myeloma (MM). B-cell maturation antigen (BCMA) is expressed in most cases of MM. We conducted the first-in-humans clinical trial of chimeric antigen receptor (CAR) T cells targeting BCMA. T cells expressing the CAR used in this work (...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Ali, Syed Abbas, Shi, Victoria, Maric, Irina, Wang, Michael, Stroncek, David F., Rose, Jeremy J., Brudno, Jennifer N., Stetler-Stevenson, Maryalice, Feldman, Steven A., Hansen, Brenna G., Fellowes, Vicki S., Hakim, Frances T., Gress, Ronald E., Kochenderfer, James N.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2016
Sujets:
Clinical Trials and Observations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043125/
https://ncbi.nlm.nih.gov/pubmed/27412889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-04-711903
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