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CD27 stimulation promotes the frequency of IL-7R expressing memory precursors and prevents IL-12 mediated loss of CD8(+) T cell memory in the absence of CD4(+) T cell help

Fully functional CD8(+) T cell memory is highly dependent upon CD4(+) T cell support. CD4(+) T cells play a critical role in inducing the expression of CD70, the ligand for CD27, on dendritic cells. Here we demonstrate that CD27 stimulation during primary CD8(+) T cell responses regulates the abilit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Dong, Han, Franklin, Nathan. A., Roberts, Drew J., Yagita, Hideo, Glennie, Martin J., Bullock, Timothy N.J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326605/
https://ncbi.nlm.nih.gov/pubmed/22422886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103329
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