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CD27 stimulation promotes the frequency of IL-7R expressing memory precursors and prevents IL-12 mediated loss of CD8(+) T cell memory in the absence of CD4(+) T cell help
Fully functional CD8(+) T cell memory is highly dependent upon CD4(+) T cell support. CD4(+) T cells play a critical role in inducing the expression of CD70, the ligand for CD27, on dendritic cells. Here we demonstrate that CD27 stimulation during primary CD8(+) T cell responses regulates the abilit...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326605/ https://ncbi.nlm.nih.gov/pubmed/22422886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103329 |
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