A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines

INTRODUCTION: Inhibiting the enzyme Fatty Acid Synthase (FASN) leads to apoptosis of breast carcinoma cells, and this is linked to human epidermal growth factor receptor 2 (HER2) signaling pathways in models of simultaneous expression of FASN and HER2. METHODS: In a xenograft model of breast carcino...

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Main Authors: Puig, Teresa, Aguilar, Helena, Cufí, Sílvia, Oliveras, Glòria, Turrado, Carlos, Ortega-Gutiérrez, Sílvia, Benhamú, Bellinda, López-Rodríguez, María Luz, Urruticoechea, Ander, Colomer, Ramon
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2011
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326573/
https://ncbi.nlm.nih.gov/pubmed/22177475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3077
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