Dual Fatty Acid Synthase and HER2 Signaling Blockade Shows Marked Antitumor Activity against Breast Cancer Models Resistant to Anti-HER2 Drugs

Blocking the enzyme Fatty Acid Synthase (FASN) leads to apoptosis of HER2-positive breast carcinoma cells. The hypothesis is that blocking FASN, in combination with anti-HER2 signaling agents, would be an effective antitumor strategy in preclinical HER2+ breast cancer models of trastuzumab and lapat...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Blancafort, Adriana, Giró-Perafita, Ariadna, Oliveras, Glòria, Palomeras, Sònia, Turrado, Carlos, Campuzano, Òscar, Carrión-Salip, Dolors, Massaguer, Anna, Brugada, Ramon, Palafox, Marta, Gómez-Miragaya, Jorge, González-Suárez, Eva, Puig, Teresa
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479882/
https://ncbi.nlm.nih.gov/pubmed/26107737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131241
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