Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

AcrAB-TolC is the major efflux protein complex in Escherichia coli extruding a vast variety of antimicrobial agents from the cell. The inner membrane component AcrB is a homotrimer, and it has been postulated that the monomers cycle consecutively through three conformational stages designated loose...

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Bibliographic Details
Main Authors: Eicher, Thomas, Cha, Hi-jea, Seeger, Markus A., Brandstätter, Lorenz, El-Delik, Jasmin, Bohnert, Jürgen A., Kern, Winfried V., Verrey, François, Grütter, Markus G., Diederichs, Kay, Pos, Klaas M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326505/
https://ncbi.nlm.nih.gov/pubmed/22451937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114944109
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