Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response

Toll-like receptor 3 (TLR3) mediates antiviral response by recognizing double-stranded RNA. Its cytoplasmic domain is tyrosine phosphorylated upon ligand binding and initiates downstream signaling via the adapter TIR-containing adaptor inducing interferon–β (TRIF). However, the kinase responsible fo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lee, Koon-Guan, Xu, Shengli, Kang, Zi-Han, Huo, Jianxin, Huang, Mei, Liu, Dingxiang, Takeuchi, Osamu, Akira, Shizuo, Lam, Kong-Peng
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326448/
https://ncbi.nlm.nih.gov/pubmed/22454496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119238109
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