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Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response
Toll-like receptor 3 (TLR3) mediates antiviral response by recognizing double-stranded RNA. Its cytoplasmic domain is tyrosine phosphorylated upon ligand binding and initiates downstream signaling via the adapter TIR-containing adaptor inducing interferon–β (TRIF). However, the kinase responsible fo...
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| Glavni autori: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326448/ https://ncbi.nlm.nih.gov/pubmed/22454496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119238109 |
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