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Phospholipase Cγ2 Is Critical for Dectin-1-mediated Ca(2+) Flux and Cytokine Production in Dendritic Cells
Dectin-1 is a C-type lectin that recognizes β-glucan in the cell walls of fungi and plays an important role in anti-fungal immunity. It signals via tyrosine kinase Syk and adaptor protein Card9 to activate NF-κB leading to proinflammatory cytokine production in dendritic cells (DCs). Other than this...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2652331/ https://ncbi.nlm.nih.gov/pubmed/19136564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806650200 |
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