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Effect of molecular weight of amine end-modified poly(β-amino ester)s on gene delivery efficiency and toxicity

Amine end-modified poly(ß-amino ester)s (PBAEs) have generated interest as efficient, biodegradable polymeric carriers for plasmid DNA (pDNA). For cationic, non-degradable polymers, such as polyethylenimine (PEI), the polymer molecular weight (MW) and molecular weight distribution (MWD) significantl...

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Bibliografski detalji
Glavni autori: Eltoukhy, Ahmed A., Siegwart, Daniel J., Alabi, Christopher A., Rajan, Jay S., Langer, Robert, Anderson, Daniel G.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326358/
https://ncbi.nlm.nih.gov/pubmed/22341939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2012.01.046
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