New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats

Myotonic Dystrophy type I (DM1) is caused by an abnormal expansion of CTG triplets in the 3′ UTR of the dystrophia myotonica protein kinase (DMPK) gene, leading to the aggregation of the mutant transcript in nuclear RNA foci. The expanded mutant transcript promotes the sequestration of the MBNL1 spl...

Full description

Saved in:
Bibliographic Details
Main Authors: Laurent, François-Xavier, Sureau, Alain, Klein, Arnaud F., Trouslard, François, Gasnier, Erwan, Furling, Denis, Marie, Joëlle
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326330/
https://ncbi.nlm.nih.gov/pubmed/22156369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1228
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items