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Single-molecule study of the CUG repeat–MBNL1 interaction and its inhibition by small molecules
Effective drug discovery and optimization can be accelerated by techniques capable of deconvoluting the complexities often present in targeted biological systems. We report a single-molecule approach to study the binding of an alternative splicing regulator, muscleblind-like 1 protein (MBNL1), to (C...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711446/ https://ncbi.nlm.nih.gov/pubmed/23661680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt330 |
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