The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA

Non-sense-mediated mRNA decay (NMD) is a mechanism of translation-dependent mRNA surveillance in eukaryotes: it degrades mRNAs with premature termination codons (PTCs) and contributes to cellular homeostasis by downregulating a number of physiologically important mRNAs. In the NMD pathway, Upf prote...

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Detalhes bibliográficos
Main Authors: Geißler, Verena, Altmeyer, Simone, Stein, Benjamin, Uhlmann-Schiffler, Heike, Stahl, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763533/
https://ncbi.nlm.nih.gov/pubmed/23788676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt538
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