MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain

Methyl-CpG-binding protein 2 (MeCP2) is a chromatin-binding protein that mediates transcriptional regulation, and is highly abundant in brain. The nature of its binding to reconstituted templates has been well characterized in vitro. However, its interactions with native chromatin are less understoo...

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Autores principales: Thambirajah, Anita A., Ng, Marlee K., Frehlick, Lindsay J., Li, Andra, Serpa, Jason J., Petrotchenko, Evgeniy V., Silva-Moreno, Begonia, Missiaen, Kristal K., Borchers, Christoph H., Adam Hall, J., Mackie, Ryan, Lutz, Frank, Gowen, Brent E., Hendzel, Michael, Georgel, Philippe T., Ausió, Juan
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326294/
https://ncbi.nlm.nih.gov/pubmed/22144686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1066
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