MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain

Methyl-CpG-binding protein 2 (MeCP2) is a chromatin-binding protein that mediates transcriptional regulation, and is highly abundant in brain. The nature of its binding to reconstituted templates has been well characterized in vitro. However, its interactions with native chromatin are less understoo...

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Detalhes bibliográficos
Main Authors: Thambirajah, Anita A., Ng, Marlee K., Frehlick, Lindsay J., Li, Andra, Serpa, Jason J., Petrotchenko, Evgeniy V., Silva-Moreno, Begonia, Missiaen, Kristal K., Borchers, Christoph H., Adam Hall, J., Mackie, Ryan, Lutz, Frank, Gowen, Brent E., Hendzel, Michael, Georgel, Philippe T., Ausió, Juan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326294/
https://ncbi.nlm.nih.gov/pubmed/22144686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1066
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