MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain

Methyl-CpG-binding protein 2 (MeCP2) is a chromatin-binding protein that mediates transcriptional regulation, and is highly abundant in brain. The nature of its binding to reconstituted templates has been well characterized in vitro. However, its interactions with native chromatin are less understoo...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Thambirajah, Anita A., Ng, Marlee K., Frehlick, Lindsay J., Li, Andra, Serpa, Jason J., Petrotchenko, Evgeniy V., Silva-Moreno, Begonia, Missiaen, Kristal K., Borchers, Christoph H., Adam Hall, J., Mackie, Ryan, Lutz, Frank, Gowen, Brent E., Hendzel, Michael, Georgel, Philippe T., Ausió, Juan
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Oxford University Press 2012
Θέματα:
Gene Regulation, Chromatin and Epigenetics
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326294/
https://ncbi.nlm.nih.gov/pubmed/22144686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1066
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