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Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin.
Doxorubicin, a DNA-intercalator, is one of several anti-cancer drugs that have been found to stabilizes topoisomerase II cleavage complexes at drug-specific DNA sites. The distribution and DNA sequence environments of doxorubicin-stabilized sites were determined in the SV40 genome. The sites were fo...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1990
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC332618/ https://ncbi.nlm.nih.gov/pubmed/2174543 |
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