Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin.
Doxorubicin, a DNA-intercalator, is one of several anti-cancer drugs that have been found to stabilizes topoisomerase II cleavage complexes at drug-specific DNA sites. The distribution and DNA sequence environments of doxorubicin-stabilized sites were determined in the SV40 genome. The sites were fo...
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| Publié dans: | Nucleic Acids Res |
|---|---|
| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
1990
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| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC332618/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2174543/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/18.22.6611 |
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