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Preparation, crystallization and preliminary X-ray diffraction studies of the glycosylated form of human interleukin-23

Interleukin-23 (IL-23), a member of the IL-12 family, is a heterodimeric cytokine composed of p19 and p40 subunits. IL-23 plays crucial roles in the activation, proliferation and survival of IL-17-producing helper T cells which induce various autoimmune diseases. Human p19 and p40 subunits were clon...

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Main Authors: Shirouzono, Takumi, Chirifu, Mami, Nakamura, Chiharu, Yamagata, Yuriko, Ikemizu, Shinji
Formato: Artigo
Idioma:Inglês
Publicado: International Union of Crystallography 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325813/
https://ncbi.nlm.nih.gov/pubmed/22505413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112005295
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