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Preparation, crystallization and preliminary X-ray diffraction studies of the glycosylated form of human interleukin-23
Interleukin-23 (IL-23), a member of the IL-12 family, is a heterodimeric cytokine composed of p19 and p40 subunits. IL-23 plays crucial roles in the activation, proliferation and survival of IL-17-producing helper T cells which induce various autoimmune diseases. Human p19 and p40 subunits were clon...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
International Union of Crystallography
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3325813/ https://ncbi.nlm.nih.gov/pubmed/22505413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112005295 |
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