A Pharmacological Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth

The threonine endopeptidase Taspase1 has a critical role in cancer cell proliferation and apoptosis. In this study, we developed and evaluated small molecule inhibitors of Taspase1 as a new candidate class of therapeutic modalities. Genetic deletion of Taspase1 in the mouse produced no overt deficie...

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Hauptverfasser: Chen, David Y., Lee, Yishan, Van Tine, Brian A., Searleman, Adam C., Westergard, Todd D., Liu, Han, Tu, Ho-Chou, Takeda, Shugaku, Dong, Yiyu, Piwnica-Worms, David R., Oh, Kyoung J., Korsmeyer, Stanley J., Hermone, Ann, Gussio, Richard, Shoemaker, Robert H., Cheng, Emily H.-Y., Hsieh, James J.-D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325786/
https://ncbi.nlm.nih.gov/pubmed/22166309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2584
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