Antigen-specific antibody responses in B-1a and their relationship to natural immunity

B-1a cells are primarily thought of as natural antibody-producing cells. However, we now show that appropriate antigenic stimulation induces IgM and IgG B-1a antibody responses and long-lived T-independent antigen-specific B-1a memory that differs markedly from canonical B-2 humoral immunity. Thus,...

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Detalhes bibliográficos
Main Authors: Yang, Yang, Ghosn, Eliver Eid Bou, Cole, Leah E., Obukhanych, Tetyana V., Sadate-Ngatchou, Patricia, Vogel, Stefanie N., Herzenberg, Leonard A., Herzenberg, Leonore A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325670/
https://ncbi.nlm.nih.gov/pubmed/22421134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121631109
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