RNA–protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNA
Ribozyme activity in vivo depends on achieving high-level expression, intracellular stability, target colocalization, and cleavage site access. At present, target site selection is problematic because of unforeseeable secondary and tertiary RNA structures that prevent cleavage. To overcome this desi...
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| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2001
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33254/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11344300/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.091411398 |
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