RNA–protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNA

Ribozyme activity in vivo depends on achieving high-level expression, intracellular stability, target colocalization, and cleavage site access. At present, target site selection is problematic because of unforeseeable secondary and tertiary RNA structures that prevent cleavage. To overcome this desi...

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Dettagli Bibliografici

Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Warashina, Masaki, Kuwabara, Tomoko, Kato, Yoshio, Sano, Masayuki, Taira, Kazunari
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33254/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11344300/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.091411398
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