RNA–protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNA

Ítems similars

• Significantly higher activity of a cytoplasmic hammerhead ribozyme than a corresponding nuclear counterpart: engineered tRNAs with an extended 3′ end can be exported efficiently and specifically to the cytoplasm in mammalian cells
  per: Kuwabara, Tomoko, et al.
  Publicat: (2001)
• tRNA(Val)-heterodimeric maxizymes with high potential as geneinactivating agents: Simultaneous cleavage at two sites in HIV-1 tat mRNA in cultured cells
  per: Kuwabara, Tomoko, et al.
  Publicat: (1999)
• Measurements of weak interactions between truncated substrates and a hammerhead ribozyme by competitive kinetic analyses: implications for the design of new and efficient ribozymes with high sequence specificity
  per: Kasai, Yasuhiro, et al.
  Publicat: (2002)
• Delta ribozyme has the ability to cleave in transan mRNA.
  per: Roy, G, et al.
  Publicat: (1999)
• Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to the cleavage of BCR-ABL chimeric L6 (b2a2) mRNA.
  per: Kuwabara, T, et al.
  Publicat: (1997)