RNA–protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNA

Ribozyme activity in vivo depends on achieving high-level expression, intracellular stability, target colocalization, and cleavage site access. At present, target site selection is problematic because of unforeseeable secondary and tertiary RNA structures that prevent cleavage. To overcome this desi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Warashina, Masaki, Kuwabara, Tomoko, Kato, Yoshio, Sano, Masayuki, Taira, Kazunari
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33254/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11344300/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.091411398
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