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RNA–protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNA

Ribozyme activity in vivo depends on achieving high-level expression, intracellular stability, target colocalization, and cleavage site access. At present, target site selection is problematic because of unforeseeable secondary and tertiary RNA structures that prevent cleavage. To overcome this desi...

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Detalles Bibliográficos
Main Authors: Warashina, Masaki, Kuwabara, Tomoko, Kato, Yoshio, Sano, Masayuki, Taira, Kazunari
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC33254/
https://ncbi.nlm.nih.gov/pubmed/11344300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.091411398
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