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RNA–protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNA
Ribozyme activity in vivo depends on achieving high-level expression, intracellular stability, target colocalization, and cleavage site access. At present, target site selection is problematic because of unforeseeable secondary and tertiary RNA structures that prevent cleavage. To overcome this desi...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC33254/ https://ncbi.nlm.nih.gov/pubmed/11344300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.091411398 |
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