Human Monoclonal Antibodies to a Novel Cluster of Conformational Epitopes on HCV E2 with Resistance to Neutralization Escape in a Genotype 2a Isolate

The majority of broadly neutralizing antibodies to hepatitis C virus (HCV) are against conformational epitopes on the E2 glycoprotein. Many of them recognize overlapping epitopes in a cluster, designated as antigenic domain B, that contains residues G530 and D535. To gain information on other region...

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Autors principals: Keck, Zhen-yong, Xia, Jinming, Wang, Yong, Wang, Wenyan, Krey, Thomas, Prentoe, Jannick, Carlsen, Thomas, Li, Angela Ying-Jian, Patel, Arvind H., Lemon, Stanley M., Bukh, Jens, Rey, Felix A., Foung, Steven K. H.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325216/
https://ncbi.nlm.nih.gov/pubmed/22511875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002653
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