Cooperativity in Virus Neutralization by Human Monoclonal Antibodies to Two Adjacent Regions Located at the Amino Terminus of Hepatitis C Virus E2 Glycoprotein

A challenge for hepatitis C virus (HCV) vaccine development is defining conserved epitopes that induce protective antibodies against this highly diverse virus. An envelope glycoprotein (E2) segment located at amino acids (aa) 412 to 423 contains highly conserved neutralizing epitopes. While polyclon...

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Bibliografske podrobnosti
Main Authors: Keck, Zhenyong, Wang, Wenyan, Wang, Yong, Lau, Patrick, Carlsen, Thomas H. R., Prentoe, Jannick, Xia, Jinming, Patel, Arvind H., Bukh, Jens, Foung, Steven K. H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536422/
https://ncbi.nlm.nih.gov/pubmed/23097455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01941-12
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