Cooperativity in Virus Neutralization by Human Monoclonal Antibodies to Two Adjacent Regions Located at the Amino Terminus of Hepatitis C Virus E2 Glycoprotein

A challenge for hepatitis C virus (HCV) vaccine development is defining conserved epitopes that induce protective antibodies against this highly diverse virus. An envelope glycoprotein (E2) segment located at amino acids (aa) 412 to 423 contains highly conserved neutralizing epitopes. While polyclon...

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Bibliographic Details
Main Authors: Keck, Zhenyong, Wang, Wenyan, Wang, Yong, Lau, Patrick, Carlsen, Thomas H. R., Prentoe, Jannick, Xia, Jinming, Patel, Arvind H., Bukh, Jens, Foung, Steven K. H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536422/
https://ncbi.nlm.nih.gov/pubmed/23097455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01941-12
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