Non-random Escape Pathways from a Broadly Neutralizing Human Monoclonal Antibody Map to a Highly Conserved Region on the Hepatitis C Virus E2 Glycoprotein Encompassing Amino Acids 412–423

A challenge for hepatitis C virus (HCV) vaccine development is to define epitopes that are able to elicit protective antibodies against this highly diverse virus. The E2 glycoprotein region located at residues 412–423 is conserved and antibodies to 412–423 have broadly neutralizing activities. Howev...

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Autors principals: Keck, Zhen-yong, Angus, Allan G. N., Wang, Wenyan, Lau, Patrick, Wang, Yong, Gatherer, Derek, Patel, Arvind H., Foung, Steven K. H.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133389/
https://ncbi.nlm.nih.gov/pubmed/25122476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004297
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