Mapping a Region of Hepatitis C Virus E2 That Is Responsible for Escape from Neutralizing Antibodies and a Core CD81-Binding Region That Does Not Tolerate Neutralization Escape Mutations

Understanding the interaction between broadly neutralizing antibodies and their epitopes provides a basis for the rational design of a preventive hepatitis C virus (HCV) vaccine. CBH-2, HC-11, and HC-1 are representatives of antibodies to overlapping epitopes on E2 that mediate neutralization by blo...

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Autors principals: Keck, Zhen-Yong, Saha, Anasuya, Xia, Jinming, Wang, Yong, Lau, Patrick, Krey, Thomas, Rey, Felix A., Foung, Steven K. H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3187491/
https://ncbi.nlm.nih.gov/pubmed/21813602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05259-11
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