Cooperative Cross-Bridge Activation of Thin Filaments Contributes to the Frank-Starling Mechanism in Cardiac Muscle

Myosin cross-bridges play an important role in the regulation of thin-filament activation in cardiac muscle. To test the hypothesis that sarcomere length (SL) modulation of thin-filament activation by strong-binding cross-bridges underlies the Frank-Starling mechanism, we inhibited force and strong...

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Bibliographic Details
Main Authors: Smith, L., Tainter, C., Regnier, M., Martyn, D.A.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2009
Subjects:
Muscle, Molecular Motors and Cell Motility
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325146/
https://ncbi.nlm.nih.gov/pubmed/19413974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.02.018
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