Coupling of Adjacent Tropomyosins Enhances Cross-Bridge-Mediated Cooperative Activation in a Markov Model of the Cardiac Thin Filament

We developed a Markov model of cardiac thin filament activation that accounts for interactions among nearest-neighbor regulatory units (RUs) in a spatially explicit manner. Interactions were assumed to arise from structural coupling of adjacent tropomyosins (Tms), such that Tm shifting within each R...

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Detalles Bibliográficos
Main Authors: Campbell, Stuart G., Lionetti, Fred V., Campbell, Kenneth S., McCulloch, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2010
Assuntos:
Muscle, Motility, and Motor Proteins
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872217/
https://ncbi.nlm.nih.gov/pubmed/20483334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.02.010
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