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The prohormone proenkephalin possesses differential conformational features of subdomains revealed by rapid H-D exchange mass spectrometry

Active enkephalin and related peptide hormones or neurotransmitters are generated by proteolytic processing of inactive prohormone precursors. Little is known about the relative accessibilities of prohormone cleavage sites and conformations of subdomains that undergo proteolytic processing. Therefor...

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Autores principales: Lu, Weiya D, Liu, Tong, Li, Sheng, Woods, Virgil L, Hook, Vivian
Formato: Artigo
Lenguaje:Inglês
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324762/
https://ncbi.nlm.nih.gov/pubmed/22102294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2000
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