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The prohormone proenkephalin possesses differential conformational features of subdomains revealed by rapid H-D exchange mass spectrometry

Active enkephalin and related peptide hormones or neurotransmitters are generated by proteolytic processing of inactive prohormone precursors. Little is known about the relative accessibilities of prohormone cleavage sites and conformations of subdomains that undergo proteolytic processing. Therefor...

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Hlavní autoři: Lu, Weiya D, Liu, Tong, Li, Sheng, Woods, Virgil L, Hook, Vivian
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley Subscription Services, Inc., A Wiley Company 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324762/
https://ncbi.nlm.nih.gov/pubmed/22102294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2000
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