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Rapid characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry

Protein function is dictated by protein conformation. For the protein biopharmaceutical industry, therefore, it is important to have analytical tools that can detect changes in protein conformation rapidly, accurately and with high sensitivity. In this paper we show that hydrogen/deuterium exchange...

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Autores principales: Houde, Damian, Arndt, Joseph, Domeier, Wayne, Berkowitz, Steven, Engen, John R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779575/
https://ncbi.nlm.nih.gov/pubmed/19265386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac802575y
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