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Differential Accessibilities of Dibasic Prohormone Processing Sites of Proenkephalin to the Aqueous Environment Revealed by H-D Exchange Mass Spectrometry

Proenkephalin (PE) is a prohormone containing dibasic sites that are cleaved by proteases to generate peptide neurotransmitters and hormones. Little is known about the conformational features of such protease cleavage sites within prohormone substrates. Therefore, the goal of this study was to inves...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Lu, Weiya D., Asmus, Kyle, Hwang, Shin-Rong, Li, Sheng, Woods, Virgil L., Hook, Vivian
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752437/
https://ncbi.nlm.nih.gov/pubmed/19173595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801888j
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