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Differential Accessibilities of Dibasic Prohormone Processing Sites of Proenkephalin to the Aqueous Environment Revealed by H-D Exchange Mass Spectrometry
Proenkephalin (PE) is a prohormone containing dibasic sites that are cleaved by proteases to generate peptide neurotransmitters and hormones. Little is known about the conformational features of such protease cleavage sites within prohormone substrates. Therefore, the goal of this study was to inves...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2752437/ https://ncbi.nlm.nih.gov/pubmed/19173595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801888j |
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