The role of distinct p185(neu) extracellular subdomains for dimerization with the epidermal growth factor (EGF) receptor and EGF-mediated signaling

The extracellular domain of p185(c-neu) can be viewed as a complex structure of four subdomains, two of which are cysteine-rich subdomains. We have investigated the contribution of these distinct p185(c-neu) extracellular subdomains to p185/epidermal growth factor receptor (EGFR) heteromer formation...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Kumagai, Toru, Davis, James G., Horie, Takeo, O'Rourke, Donald M., Greene, Mark I.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33246/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11320205/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.071060598
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